![]() ![]() Seizure and death have been reported in young children following oral ingestion, overexposure, or altered skin barrier. 1, 3 However, several reports exist on central nervous system toxicity presented as nausea, vomiting, headache, irritability, insomnia, and seizure. 5, 6 Gamma benzene hexachloride 1% lotion (lindane) is recommended as second-line therapy for scabies in children. 2 Crotamiton 10% cream is approved by the US Food and Drug Administration for treatment of scabies in adults, but there is very little research on its use in children. 1, 2 The main disadvantage is that it is unpleasant to use-smelly and cosmetically not acceptable to many patients. Sulfur (5% to 10%) in an ointment base is safe for infants and children. 1, 4 Various agents, most of which are topical, have been used to treat scabies, including sulfur, gamma benzene hexachloride (lindane), crotamiton, benzyl benzoate, malathion, ivermectin, and permethrin. ![]() 2 Further, little research compares the safety and efficacy of scabies treatments in infants and small children. Many drugs used in adults cannot be used in children because of diverse safety profiles. Treating scabies in infants and children is challenging. 2 It is highly prevalent in children younger than 2 years of age. 1 It is common worldwide, with an estimated 300 million people infected each year. It can be concluded that the application of permethrin 5% cream twice daily for 2 months can be as effective and reliable as metronidazole in the treatment of rosacea and a greater benefit can be gained when it is combined with other systemic and/or topical treatments.Scabies is a common parasitic skin infection caused by the Sarcoptes scabiei mite, resulting in an intensely pruritic skin eruption with a characteristic distribution pattern. However, it had no effect on telangiectasia, rhinophyma and pustules. The effect of permethrin 5% cream on erythema and papules was found to be more effective than placebo and as effective as metronidazole 0.75% gel. folliculorum was superior to that of metronidazole 0.75% gel. folliculorum were determined at baseline and on days 15, 30, 45 and 60. The mean scores of erythema and the mean numbers of papules, pustules and D. folliculorum were recorded at each visit. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and D. Two months of treatment were planned, and the patients were invited to the clinic for fortnightly controls. All patients were also given SPF 20 cream for protection against sunlight. Twenty-three patients were given permethrin 5% cream (Zalvor 5% skin cream, 20 patients metronidazole 0.75% gel (Roza gel and 20 patients placebo cream (Basis cream, in packages looking identical to those of metronidazole and permethrin creams, and were recommended to apply them to their faces twice a day. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and Demodex folliculorum were determined. Patients were randomly assigned into permethrin (n = 23), metronidazole (n = 20) and placebo (n = 20) groups. This study included 63 patients diagnosed as having papulopustular rosacea based on the clinical and histological findings. Permethrin 5% cream used against human ectoparasites suggests that it may be effective in papulopustular rosacea. ![]()
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